Elsewhere, England are down to a near fourth-choice second row combination, with Lilli Ives Campion, who has suffered a knee injury, becoming the latest lock to be sidelined.
Zoe Stratford, Abbie Ward and Rosie Galligan are all pregnant, while Morwenna Talling has been ruled out of the tournament with a leg injury sustained in the opening-weekend win over Ireland.
Abi Burton, a back row, and Delaney Burns, who won the most recent of her three previous caps back in 2023, will be paired in the engine room.
The fly-half shirt changes hands once more with Holly Aitchison back in at 10 in place of rival Zoe Harrison.
Props MacKenzie Carson and Sarah Bern are promoted off the bench and into the starting line-up along with 113-cap flanker Marlie Packer.
Despite the disruption and debuts, England’s strength in depth is likely to be enough to see off a Wales side who have finished bottom of the table in the past two Six Nations campaigns.
England: Kildunne; David, Jones (c), Rowland, Moloney-MacDonald; Aitchison, L Packer; Carson, Cokayne, Bern, Burton, Burns, Kabeya, M Packer, Feaunati.
Replacements: Powell, Clifford, Muir, Lutui, Short, Robinson, Harrison, Breach
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